The couple, from Burnley, Lancashire, died while staying in the Red Sea resort of Hurghada, the tour operator said.
One was a long-serving employee of Thomas Cook.
The circumstances of their deaths have not been released. Investigations into what happened are continuing.
Ingo Burmester, chief of Thomas Cook UK, said: “We are deeply saddened by the deaths of two of our customers while on holiday in Hurghada in Egypt, one of whom was a loyal and long-serving member of our Thomas Cook family.
“Our focus is on fully supporting their loved ones. We are urgently investigating with the hotel and supporting the local authorities.”