Edinburgh Inspiring Capital took tenth and last place in the race, which is part of a 15-race series taking place over a year.
Crew member Nick Barclay, 30, who is from Cape Town, said he was delighted to call in at his home port.
He said: “I never expected to feel so homesick and to wake up this morning and see Table Mountain was just spectacular.
“To be able to point out Signal Hill and Lion’s Head – and my apartment – was just amazing. We’re in the V&A Waterfront where I do all my shopping and I’ll be taking some of the crew to show them around my city later.”
Mr Barclay, who had a kidney transplant in 2005, is one of the Transplant Ambassadors, a team of transplantees, surgeons and other medics who have joined the Edinburgh crew to highlight the way that transplants transform lives.