High Street has reopened in both directions between St Mary’s Street and Blackfriars Street.
The road was closed after it a bus apparently hit some scaffolding nearby.
A number of buses were diverted but the route has since reopened.
The road has been closed for close to two hours following the incident just before 10:30am.
A Police Scotland spokesperson said: “Police in Edinburgh area currently in attendance in the High Street area following a minor road traffic collision involving a bus. High Street is currently closed and the public are asked to avoid the area where possible.”