Craig Gordon, Michael Smith and Liam Boyce will drop out due to international duty, while Peter Haring, Steven Naismith and Andy Halliday could be rested after starting in the weekend’s 2-1 win over Inverness CT.
On top of that, three of the attacking players, Josh Ginnelly, Jordan Roberts and Jamie Walker are all likely to miss out. It should present fringe players wit the opportunity to gain some first-team football with the team needing just a point a ensure progress to the knock-out stages.
Scroll down and click through for what we think the starting XI will be in Methil with seven changes.
1. GK - Ross Stewart
With Craig Gordon on international duty, Stewart will likely deputise after playing against Raith Rovers. Photo: Mark Scates - SNS Group
2. RB - Jamie Brandon
With Michael Smith out, Brandon will be the likely deputy. Photo: Rob Casey - SNS Group
3. CB - Craig Halkett
Ever present so far for Neilson and could take the captain’s armband. Photo: Rob Casey - SNS Group
4. CB - Christophe Berra
The former skipper is in line for his first Hearts appearance since the Boxing Day defeat to Hibs last year. Photo: Ross Parker - SNS Group