The building was found “well alight” and a total of 10 fire appliances have been sent to the scene on Rose Street in the city centre.
No casualties have been reported and some streets in the area have been closed.
We take a look inside the grand old building that has sat proudly on Princes Street.
. A visit from Gracie Fields
Singer Gracie Fields can be seen in the television lounge of Jenners with her friends Mrs Mary Davey and Miss Greta Beattie. Year: 1952 Photo: TSPL
. A royal visit
In honour of Queen Elizabeth II visiting Edinburgh, coronation decorations adorn the East End of Princes Street, including the famous department store. Year: 1953 Photo: TSPL
. A hairdressers
The hairdressers salon in Jenners could accommodate up to 10 clients. You can see three women here getting their hair done. Year: 1955 Photo: TSPL
. Festival decorations
Here, you can see lantern style Edinburgh Festival decorations that have been hung up outside of Jenners on Princes Street. Year: 1957 Photo: TSPL
. Extension planning
It was announced that Jenners department store was to expand and take over the Royal Hotel in May. Year: 1960 Photo: TSPL
13. The iconic exterior
It’s clear to see that the incredible architecture of the exterior of the department store hasn’t changed throughout its time on Princes Street. Year: 1998 Photo: Alan Ledgerwood
14. A Ferrari in Jenners
A Ferrari 465M is seen here being driven through the men's department to launch the stores Italian ‘La Dolce Vita’ promotion. Year: 2001 Photo: Jon Savage
15. The famous Christmas tree
Jenners is famous for having some of the biggest and best Christmas decorations, including a 40 foot tree. Year: 2003 Photo: Jon Savage
16. Lit up pink
In honour of Breast Cancer Awareness Month, Jenners department store was lit up pink for ‘Pinktober’. Year: 2012 Photo: Jane Barlow