The 48-year-old was driving on the A199 near Haddington when his vehicle collided with the house at about 7.55pm on Saturday.
Emergency services attended but he was pronounced dead at the scene.
No one in the house was injured in the crash.
A police spokeswoman said: “Officers were called to the A199 near Haddington at around 7.55pm on Saturday, 15 May after a vehicle collided with a house.
“The driver and sole occupant of the van, a 48-year-old man, was pronounced dead at the scene. Nobody from within the house was injured.
“Enquiries are ongoing into the cause of the crash and anyone who witnessed the Vauxhall Combo van travelling eastbound on the A199 and potentially has dashcam footage, or who saw the collision, should contact Police Scotland on 101 and quote incident number 3797 of 15 May.”