Some sites will require free tickets booked in advance, while some will allow visitors to simply turn up.
From a buddhist meditation centre to a croquet club to a busy courtroom, below are some ideas for places to visit this Saturday and Sunday.
1. Informatics Forum
The University of Edinburgh Informatics Forum will host tours bringing visitors up to the stunning views of the city from the building's garden roof terrace.
10 Crichton Street, EH8 9AB, open Sunday 10.30am-2.30pm.
2. Tibetan Buddhist Meditation Centre
This Georgian building was originally opened in 1805 as the first Bank of Leith. It is now open to all faiths for prayer, meditation and other activites to benefit the body and spirit. Half-hour doors will run at 2.30pm and 3.30pm before a talk in the shrine room.
25 Bernard Street, EH6 6SH, open Sunday 2pm-5pm.
3. Vennel Churchyard
Guided tours of the Vennel Churchyard will reveal stories of witches, sea captains, sailors and many others who came from near or far to end up in this final resting place.
The Vennel, South Queensferry, EH30 9HT, open Saturday 10am-4pm.
4. MRC Institute of Genetics and Molecular Medicine
This centre links three University of Edinburgh units: The CRUK Edinburgh Cancer Centre, the MRC Human Genetics Unit, and the Centre for Genomic and Experimental Medicine. The event will include talks, poster presentations and tours.
Western General Hospital Campus, Crewe Road, EH4 2XR, open Saturday 10am-5pm.