Midfielder Harry Cochrane and striker Craig Wighton are the latest casualties, joining Clevid Dikamona, Jimmy Dunne, Uche Ikpeazu and John Souttar. Arnaud Djoum is suspended, giving Craig Levein a further headache in the midfield.
Czech goalkeeper had a night to forget against Livingston but should continue between the sticks in he Granite City.
A first-half replacement for the injured Dikamona against Livingston, Hughes had a nightmare second 45 minutes but should feature against the Dons with Craig Levein struggling for fit centre-backs.
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The versatile Northern Irishman could slot into a back three as Craig Levein looks to manage without several centre-backs.
Club captain will be called upon to organise a makeshift defence and keep Sam Cosgrove quiet.
Canadian defender is likely to come back into the side in a right wingback role after sitting out the 5-0 thrashing at Livingston.
Former Luton Town man should start in the centre-right of a five-man midfield as Levein looks to keep the middle of the park congested and stifle Lewis Ferguson and Graeme Shinnie.
With Arnaud Djoum suspended and Harry Cochrane injured, Bozanic is likely to start in midfield.
On-loan Manchester United youngster will likely keep his place in the starting line-up as an attacking left wingback.
The big Austrian powerhouse is expected to patrol the area between defence and midfield, offering an extra layer of protection. Will be a threat from set-pieces with his height.
Talismanic leader should return to the starting line-up and his presence will be a big boost for Hearts.
Wily centre-forward will have to use all his experience and nous to get some change out of Scott McKenna and Andy Considine. Should benefit from the return of Naismith.