Bonnyrigg Rose boss Robbie Horn admits his players are short on confidence after fourth straight defeat
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The defeat - Rose's fourth on the trot - also saw substitute Bradley Barrett sent off with 13 minutes remaining at Cliftonhill for a second bookable offence.
The Coatbridge men gained the initiative after 15 minutes from Luke Graham's corner before the hosts doubled their lead from the penalty spot as Charlie Reilly slotted beyond Mark Weir.
However, the visitors responded immediately through Lee Currie's superb free-kick to send Rose in 2-1 down at the break.
And, despite a spirted effort in the second half which saw them go close on numerous occasions, they Midlothian club were unable to salvage a point.
Rose must now look to get back on track when they welcome Annan to New Dundas Park on Tuesday night.
"We've got to start games better," Horn said afterwards. "We've spoken about it often enough and I don't know if you talk about it too much it plants something in your head. We need to stop giving away cheap goals which we've been doing to give ourselves a chance in games.
"The players at the moment are lacking a wee bit of confidence and belief in themselves but we've had a good chat, we'll stick together and keep working hard. We've got a chance to right the wrongs on Tuesday night so there's a quick turnaround. It's not easy in this league."