Edinburgh-born Weir was diagnosed with motor neurone disease in December 2016.
The former Scotland international, who won 61 caps, used his profile to push for better research to be carried out into MND and appealed for improved care to be given to those afflicted by it.
Here, we take a pictorial look back over his life, his career and his fund-raising work for research into motor neurone disease.
9. Ultra 7 in 7 Challenge
Kevin Sinfield with Doddie Weir ahead of day one of the Ultra 7 in 7 Challenge from Murrayfield to Melrose. The former Leeds captain completed seven ultra-marathons in as many days in aid of research into Motor Neurone Disease. Photo: Euan Cherry
10. Embrace
Kevin Sinfield embraces pal Doddie Weir on day one of the Ultra 7 in 7 Challenge from Murrayfield to Melrose. Photo: Euan Cherry
11. Cockerel
Doddie Weir, right, and former Scotland team-mate Damian Cronin pose with a cockerel ahead of a Five Nations game against France in 1998. (Chris Bacon/PA) Photo: Chris Bacon
12. Helen Rollason Award
Doddie Weir (centre) receives the Helen Rollason Award from the Princess Royal during the BBC Sports Personality of the Year 2019 at The P&J Live, Aberdeen. Photo: Jane Barlow