The 60-minute programmes will see famous faces explore their personal lives and careers.
The programme was previously hosted by Morgan, who announced his departure in September after more than 100 episodes over 12 years.
Speaking about her new role, Garraway said: “I’ve always loved having the chance to talk to people, both on air and off.
“Everyone has a story to tell and the wonderful thing about this show is that you have the airtime to delve into the areas of guests’ lives that the viewers might not know about already.
“It’s also a chance to understand more about the bits we do already know about (both good and bad) and hear it in their own words.”
Garraway will also take a deep dive into her own personal life, with a follow-up to her award winning documentary Finding Derek.
The programme charted the family struggle to get Garraway’s husband Derek home from hospital after he became seriously ill with Covid-19.
A sequel, titled Caring For Derek, will see the period following Derek’s return home – April 2020 to February 2021 – which will show Garraway navigating the challenges of the social care system.
Kevin Lygo, managing director, Media and Entertainment at ITV, praised the “remarkable” Garraway and her “equally resilient family” as he announced the line-up.
Line Of Duty stars Vicky McClure and Martin Compston will appear in separate thrillers on ITV.
McLure will join Adrian Lester in explosive, six-part thriller Trigger Point, written by newcomer Daniel Brierly and produced by Jed Mercurio, about counter terrorism policing and the Metropolitan Police Bomb Disposal Squad.
Paisley-born actor Compston will appear alongside Tuppence Middleton and Rupert Penry Jones in Our House, adapted from the international best-selling novel by Louise Candlish.
Our House tells the four-part story of Fi Lawson (Middleton), who arrives home one day to find a family of strangers moving into her house and her husband, Bram (Compston), has disappeared. As the nightmare takes grip, both Bram and Fi try to make sense of the events that led to a devastating crime and how they each are going to survive the chilling truth.